Deficient nomenclature in the field of iatrogenic deficit?

Subjective adverse effects of dopamine antagonists, historical perspective and clinical significance.

Abstract

Fragmented and inconsistent terminology for subjective adverse effects of dopamine antagonists—such as apathy, emotional blunting, and loss of motivation—complicates the distinction between iatrogenic and primary symptoms. Historical terminology, including concepts like “neuroleptic dysphoria,” “neuroleptic-induced deficit syndrome,” and “akinetic depression,” highlights the overlap between desired and adverse effects and the complexity of clinical assessment. Understanding these phenomena requires consideration of neurobiological, phenomenological, and clinical perspectives, as unclear nomenclature can influence symptom evaluation and the quality of care.